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The observable consequence is the most potent weight- and glucose-lowering profile of any molecule approved before retatrutide: SURMOUNT-1 reported roughly 22.5% weight reduction at the 15 mg dose over 72 weeks 13, and SURMOUNT-5 showed tirzepatide superior to semaglutide 2.4 mg head-to-head at 72 weeks (20.2% vs 13.7%) 18

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USADA is a signatory to the World Anti-Doping Code established by the World Anti-Doping Agency (WADA), which means that USADA upholds and enforces WADA rules that govern sport around the world