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Graham SA, Pitter V, Hori JH, Stein N, Branch OH

2026 Apr 14

Practical note from our operations: We have observed that SAG-based formulations tolerate standard tableting and encapsulation temperatures without specialized nitrogen blanketing, whereas GSH batches often require in-process antioxidant addition and rapid packaging to meet label claim at release testing

A small percentage have persistent symptoms that make continued treatment untenable

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The present data demonstrate that eliminating hepatocyte DPP4 in HFHC-fed mice decreased DPP4 activity and increased intact incretins in the portal circulation and reduced HGP