According to the National Institute of Health (NIH), while GLP-1 medications have been effective in helping individuals achieve weight loss of 10-15% or greater from their baseline weight, these individuals do frequently regain weight upon stopping medication
Nausea, vomiting, constipation, and diarrhea are well-recognized effects of GLP-1 medications, especially during dose increases
Do not follow very-low-calorie diets (below 1,200 calories for women or 1,500 calories for men) without medical supervision
Are these peptides safe for long-term use
It works by slowing gastric emptying and regulating insulin and appetite, but its full systemic effects are still under investigation

Introduction Diabetes, a serious chronic disease, is growing worldwide and is now one of the top ten leading causes of death worldwide ( SCs, as the main glial cells in the peripheral nervous system, possess regenerative properties of interest and have important roles in the nervous system in coordinating the gradual formation of peripheral nerves, ensuring neuronal survival, axonal support and myelination, and promoting neurodegeneration and regeneration ( Programmed cell death (PCD) is an active death process (e.g., apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis) that occurs after a cell receives a certain stimulus or signal in order to maintain the homeostasis of the internal environment ( SCs are an important link in the pathogenesis of DPN: the role of axons SCs encapsulate all axons in peripheral nerves and maintain the long-term functional integrity of axons (26, 27)