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The first is because it is broken down in the digestive system and liver, so only a small amount of it is absorbed intact into the bloodstream
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A broader review in PMC also discusses BPC-157 as a stable gastric pentadecapeptide with substantial preclinical literature across skin wounds, burns, fistulas, tendon, ligament, muscle, bone, nerve, and blood vessel healing models
The copper component of GHK-Cu contributes directly to angiogenic processes by serving as an essential cofactor for lysyl oxidase and other enzymes involved in ECM cross-linking required for vessel maturation and stability
Avoid repeated freeze-thaw cycles and protect from light
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