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While it is believed that semaglutide leads to gastrointestinal disorders less than 5% of the time, transient, mild-to-moderate bouts of the following issues are commonplace among GLP-1 drugs: Nausea : 44% Vomiting: 25% Diarrhea: 32% Constipation: 23% Abdominal pain: 10% Fatigue, Dizziness, Headache Clinical data does not support the idea that semaglutide directly causes dizziness, headaches, or significant fatigue

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Meta-Analyses Showing Reduced Depression Scores Many meta-analyses have looked into GLP-1 receptor agonists and depression

Since its 2017 approval as a diabetes treatment, semaglutide (the generic name for Ozempic and its offshoots, Rybelsus and Wegovy) has become one of the most popular prescription drugs in the U.S

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