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Serious adverse effects have not been widely reported, but long-term safety data in humans is lacking

Cancer Cell 6 : 7584 Lim Y, Han I, Jeon J, Park H, Bahk YY, Oh ES (2004) Phosphorylation of focal adhesion kinase at tyrosine 861 is crucial for Ras transformation of fibroblasts

It's a significant, sometimes dramatic shift

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