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Class B GPCRs are important therapeutic targets
Since GLP-1 medications reduce intestinal fluid secretion, deliberately drinking more water replaces this loss and softens stool naturally
To confirm this result, we also performed div-1(RNAi) in glp-1(q224)
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GLP-1 effects include slowing gastric emptying, increasing satiety, as well as cardioprotective effects ( via inducing osteoblast activity and reduction of bone resorption via inhibition of osteoclasts ( Figure 1 )
Before experiments, the diabetic SD rats model was established by intraperitoneal injection of STZ in step with the protocol 45
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