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doi: 10.1172/JCI72434 72 AdamsJMPeiHSandovalDASeeleyRJChangRBLiberlesSDet al
Am J Clin Nutr 70 : 10161024
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The aberrant activation of Nrf2 in cancer cells leads to increased expression of Glucose-6-phosphate dehydrogenase (G6PD), transketolase (TKT), 6-phosphogluconate dehydrogenase (PGD), and other metabolic enzymes promoting glutamine and glucose metabolism in pentose phosphate pathway (PPP) and increasing synthesis of amino acids participating in metabolic reprogramming required for cell proliferation (Mitsuishi et al
These medications act on brain areas that control reward, cognition, and emotional behavior in ways that may be effective at treating substance use disorder
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