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Late-stage traction alopecia where scarring has occurred responds poorly

[4] For example, biotin-dependent enzymes facilitate the conversion of pyruvate to oxaloacetate (an important step in gluconeogenesis), the synthesis of malonyl-CoA from acetyl-CoA (the first step in fatty acid biosynthesis), and the catabolism of certain amino acids into Krebs cycle intermediates

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Dondero K, et al

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Thus, following the identification of active BAT in adult humans and the demonstration that certain depots of white adipose tissue can undergo browning, there has been recent interest in the development of approaches that induce BAT activity and promote browning [10]