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This causes high oxidative stress, mitochondrial dysfunction, and cell death of the hepatocytes.[ref] As these cells die, inflammatory cascades perpetuate the oxidative stress, leading to bleeding, fibrosis, or possibly liver failure

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This knockdown significantly reduced the increase in mitochondrial mass seen with 5FU treatment

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doi: 10.1016/j.envpol.2017.02.062 38 QinH

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Plant Cell Physiol 25:385395 Iqbal A, Yabuta Y, Takeda T, Nakano Y, Shigeoka S (2006) Hydroperoxide reduction by thioredoxin-specific glutathione peroxidase isoenzymes of Arabidopsis thaliana

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