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In the present study we have examined GSH changes using the most common rodent exposure regimen for chronic CS studies and have shown that there is a GSH adaptive response to CS that occurs very early on and can be maintained for periods of up to 4 months

Multivitamin supplementation similarly showed no improvement in radiation-related fatigue (351), while observational data from chemotherapy cohorts (e.g., SWOG S0221) raised concerns that concurrent antioxidant use during treatment may negatively influence survival, potentially by attenuating ROS-mediated cytotoxicity of chemotherapy (348) Coenzyme Q10, despite increasing plasma antioxidant levels, did not improve fatigue or quality of life outcomes, further highlighting the disconnect between biochemical antioxidant enhancement and clinical benefit (352) Although antioxidants exhibit important biological activity, supplementation has not consistently demonstrated significant benefits in breast cancer prevention or treatment, with outcomes varying according to clinical context, timing of use, and patient subgroup
The MEME program determined 9 specific putative motifs that contain 14 to 50 residues (Figure 1A
K.ZhangX.WangX
2020;7:ofaa507