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Dose titration with the glucagon-like peptide-1 agonist, liraglutide, reduces cue- and drug-induced heroin seeking in high drug-taking rats

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It warns against stopping medication without medical guidance, since an abrupt stop may itself affect hormonal balance

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However, in Sprague Dawley rats, GLP-1 monotherapy significantly increased kaolin intake compared with vehicle-treated rats and rats treated with MK-801 (Extended Data Fig

This is less common than nausea or vomiting, and symptoms typically improve within 4-8 weeks as tolerance develops