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There is no accumulation concern with either formulation at standard injectable doses

In this manuscript, the term chronobiotic is used primarily in a functional sense, referring to agents capable of modulating circadian physiology, while acknowledging that only a subset (such as melatonin) fulfills the strict definition of circadian entrainment or phase-shifting agents

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Specifically, if administered by injection, redness and swelling may occur at the injection site

Seifar, F., Dinasarapu, A

For details, see the Concerns and Cautions section of our SAMe Supplements Review