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Immunohistochemical analysis confirmed that OSR downregulated inflammatory mediators and oxidative stress markers while upregulating GPX4 and SLC7A11 expression in joint tissues.Furthermore, OSR demonstrated excellent systemic tolerability, with consistent body weight and preserved histoarchitecture across major organs, indicating minimal offtarget toxicity 32,33 .Current pharmacological treatments for OA primarily provide symptomatic relief rather than disease modification.While NSAIDs and analgesics provide transient pain relief, they are ineffective in rebuilding cartilage or interrupting the chronic inflammatory and oxidative feedback loops that propel osteoarthritic progression 34

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The organic layer was collected and evaporated to dryness under nitrogen flow

Umbilical cord blood concentrations are 24 times higher than those of maternal plasma levels

J Multidiscip Care

Also, AGEs may demonstrate different cross-linking abilities (14, 36)