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Beyond the metabolic rate reduction, hypothyroidism affects fat metabolism directly

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System Xc (a special cystine/glutamate transporter) exchanges intracellular glutamate for extracellular cystine in a 1:1 ratio (Dixon et al., 2012), driven by the high intracellular glutamate concentration rather than adenosine triphosphate (Friedmann Angeli et al., 2014)