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This works well when treating vitamin B12 deficiency

When administered as part of a supervised weight loss program, MIC B12 injections may contribute to a weight loss of 2-4 pounds per week

For example, if phenytoin levels are therapeutic, the administration of a drug competing for protein binding could double the free phenytoin level (if protein binding decreases from 90% to 80%)

Note that there is some evidence that PPS has lower efficacy in patients with Hunner lesions

Additionally, the intestinal tissue has an unstirred water layer (UWL), which is a stagnant water barrier formed between the intestinal villi surface and water molecules, significantly affecting the permeability of lipophilic compounds [8]

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