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Post: 38 yo female with PMH of HTN and Class I obesity presents for follow-up after 2 years on Zepbound 15mg

While these Phase 3 trials focus primarily on obesity and diabetes (with liver outcomes as secondary endpoints), the combination of Phase 2a liver data and Phase 3 weight loss results suggests retatrutide could become the first FDA-approved medication specifically for MASLD/NASH treatment

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Quick Answer: Weight loss injections typically cause minimal pain, described as a brief pinch or sting lasting only seconds, with most patients finding the discomfort manageable and routine after proper technique is established

This dual action is what sets it apart from earlier medications like Wegovy (semaglutide)