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Epithalon is not approved for use by the United States Food and Drug Administration (FDA) and is not typically available by prescription in that country

Cisplatin is known to interfere with the mitochondrial complex and disrupt cellular respiration, resulting in increased and unregulated levels of reactive oxygen species (ROS) (Alhowail, 2025)

The mechanism involves NAD+-dependent enzymes critical for glucose metabolism

The latter reaction is assumed to be one of the primary regulation points in the sulfate reduction, since the activity of APS reductase is the lowest of the enzymes of the sulfate reduction pathway and it has a fast turnover rate

Alexiev BA, Chou PM, Jennings LJ

The multiple linear regression analysis was performed using IBM SPSS statistics software (version 19)