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These diverse mechanisms are some of the hidden players responsible for the onset of cardiac remodeling which most frequently manifests as early-on asymptomatic diastolic dysfunction that later progresses into more severe pathological phenotype ( 2.1 Remodeling and fibrosis in DCM Long-term T2DM promotes proliferation of cardiac fibroblasts leading to interstitial extracellular matrix (ECM) deposition and myocardial interstitial fibrosis which contributes to LV anatomic and functional remodeling (39)

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In the Phase 2 trial, weight loss had not plateaued at 48 weeks (24.2% at 12 mg)