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GLP-1 exerts pleiotropic effects on innate and adaptive immune responses, endothelial function, and adipose tissue inflammation, thereby influencing multiple pathways relevant to psoriatic disease ( This immunometabolic crosstalk provides a biologically plausible link between metabolic dysfunction and musculoskeletal inflammation, and supports the hypothesis that targeting incretin pathways could interfere with disease evolution at a preclinical or early PsA

Some patients notice improved sleep and energy within a few weeks, while body composition changes and tissue repair improvements may take 24 months of consistent use

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