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One randomized controlled trial published in the Journal of Urology (Safarinejad et al., 2008) specifically looked at men with ED who did not respond to sildenafil (Viagra)
Working with an obesity medicine specialist, he says, is ideal, though he acknowledges finding one may be a challenge
Real-world results vary (diet, activity, meds like GLP-1/tirzepatide, sleep, stress)
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So in a final attempt to fix his metabolism he gave up on the drug and water-fasted for 21 straight days
Clinical trials (STEP 1) demonstrated that adults without diabetes combining semaglutide with lifestyle interventions achieved significantly greater weight reduction (approximately 15% body weight) compared to placebo with lifestyle changes alone
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