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Maintaining adequate hydration represents an important preventive measure

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However, there are no randomized controlled trials with HCC incidence as a primary endpoint, and the observed associations may be influenced by confounding factors such as weight reduction, improved glycemic control, and concomitant use of statins or other hepatoprotective agents

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Moreover, it has recently been reported that metformin inhibits the apical sodium-dependent bile acid transporter and thus may increase the concentration of bile acids in the intestine [12], which could stimulate GLP-1 secretion from L cells via the G-protein-coupled receptor TGR5 [13]