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Some studies have shown a reduction of the insulin dose and in hypoglycaemic episodes
Furthermore, these nanocarriers are capable of depleting GSH levels in the tumor microenvironment to augment stress on cells and induce cell death pathways, including ferroptosis, making cancer cells sensitive to treatment Fig
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To successfully employ an all-comers strategy moving forward, manufacturers need to ensure products have strong clinical and/or non-clinical differentiation, a robust data package that addresses a range of patient types and comorbidities, and well-funded physician and patient facing marketing campaigns
doi: 10.1185/03007995.2010.549466 166 HamiltonAPattersonSPorterDGaultVAHolscherC