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Mechanics and biology interact in intervertebral disc degeneration: A novel composite mouse model

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This mechanism raises the critical discontinuation question - does stopping GHK-Cu immediately halt enhanced collagen production returning synthesis rates to pre-treatment baseline, or does the improved dermal environment created during treatment continue supporting elevated collagen production through positive feedback mechanisms where better matrix structure itself promotes ongoing synthesis even without continuous peptide stimulation

To ensure blinding, the containers were labeled A and B by a single, blinded pharmacist, who disclosed the codes only at the end of the trial

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