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Risk of systemic copper overload is negligible when used as directed
Mechanisms include direct DNA binding, affecting transcription factor activity, and epigenetic modifications
Inagaki N, Seino Y, Takeda J, Yano H, Yamada Y, Bell GI, et al
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Winter S et al
Additionally, smaller-scale studies have explored the potential of other interventions, such as ascorbate (Vitamin C) and thiamine: in one single-center study, administration of high-dose intravenous Vitamin C during cardiopulmonary bypass (CPB) was found to reduce the formation of neutrophil extracellular traps and was associated with enhanced lung function and shorter intensive care unit (ICU) stays (184)
