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Adv Nutr 8: 971-979 Lovblad etal 1997 Retardation of myelination due to dietary vitamin B12 deficiency: cranial MRI findings Pediatr Radiol 27: 155-8 Horstemann etal 2003 Infantile cobalamin deficiency with cerebral lactate accumulation and sustained choline depletion

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Signs you might accelerate the titration In limited cases, your provider may shorten the time at a given dose level to 2-3 weeks instead of 4 if: You experience zero GI side effects at the current dose Appetite suppression is minimal (you are eating nearly the same as before) You have prior experience with GLP-1 agonists and demonstrated good tolerance Weight loss is below 0.5% per week at the current dose for 3+ weeks Accelerated titration should only be done under professional guidance

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