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Newer erythrocytes can produce sufficient NADPH because they have a higher G6PD activity

Additionally, even though Nrf2 activation was seen in vivo , aldosterone-treated rat kidneys showed significant DNA damage, showing that the response was insufficient to shield the animals from these side effects (75)

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In CBA mice, long-term administration of Epitalon preserved brain and liver mitochondrial ultrastructure, even after irradiation, suggesting real structural protection at the organ level [45]