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The human gut acts as one of the largest endocrine glands

found that once-a-week medication of exenatide had lowered the incidence of the composite outcome of all-cause death or HHF in patients without baseline HF [89]

RSL3 is able to induce ferroptosis by directly inhibiting the enzymatic activity of GPX4 through covalent interaction with selenocysteine at the active site of GPX4 (51)

To circumvent this limitation, strategies such as PEGylation or the introduction of albumin-binding motifs are actively explored to prolong the plasma half-life of these smaller constructs [18, 19]

Ongoing long-term surveillance studies will provide more definitive answers as data mature

doi:10.1016/j.dsx.2023.102834