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Thus, loss of EECs parallels the progression towards an inflammatory tissue environment
Your goal is to create a solution with a known concentration, making future dosing straightforward
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But can you control them or eliminate them
For example, EVs secreted by cerulein-stimulated acinar cells delivered miR-183-5p, which downregulated forkhead box protein O1, promoted M1 macrophage polarization, and increased macrophage infiltration into the pancreas, ultimately leading to acinar cell injury and trypsinogen activation
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