Without adequate glutathione to neutralize the ongoing flood of free radicals, the mitochondriathe powerhouses of the cellbecome damaged and dysfunctional
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124 In addition to MRG-201, Viridian Therapeutics has several other miRNA-based drugs, including MRG-106 (Cobomarsen), which targets miR-155 to inhibit tumor development, and MRG-110, which targets microRNA-92 to promote angiogenesis
These compounds are known as terpenoid coumarins, which have diverse biological activities such as antioxidant and anti-inflammatory effects and can inhibit NO-synthase in cell models, meaning they reduce the activity of the enzyme that causes the production of harmful nitric oxide and inflammation in cells, thus preventing cellular damage (14)
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