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Additionally, the same detox and metabolism triggered by the above can also cause a partial histamine breakdown and trapping of methylhistamine which can aggravate all the Sx you mention as well

First of all, the study population was mainly from Iran, and the number of participants was small, so it needs to be further verified by increasing the sample size in future studies

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Topical forms of HRT, such as oestrogen gels or suppositories, are often preferred as their absorption is not affected by gastric emptying

As systemic inflammation drops, you may see improvements in triglycerides and HDL