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Therapeutic strategies aiming at iron metabolism as a possible target in MDS and AML can be roughly distributed in four approaches: reduction of iron required for cellular functions via iron chelation, modulation of proteins involved in iron metabolism, induction of ferroptosis und exploitation of iron proteins for the delivery of antileukemic drugs ( Figure 3 )

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Oxidative Stress and Damage: A Vital Pathogenic Mechanism of CIPN It is well established that the production of reactive oxygen species (ROS) by antineoplastic agents induces apoptosis in cancer cells [14]

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