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International Journal of Cancer, 101 (1), 7-10
Lets explore the connection between B12 and autism spectrum disorder (ASD) and what it might mean for your family
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2014, 2014, p
It inhibits NOTCH1 signaling by using its GCT activity to cleave a -glutamyl-cysteine bond at glutamate 1669 of the immature NOTCH receptor, thereby preventing the essential S1 cleavage and subsequent activation ( FIGURE 6 The physiological importance of this mechanism is underscored by severe developmental phenotypes upon its disruption
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