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5.4 Comparative therapeutic efficacy The translation of therapeutic agents from animal models to clinical trials faces significant barriers

Exenatide prolonged the gastric half-emptying time in all diabetic patients without gastroparesis ( n = 20) and worsened the gastric emptying in two of ten diabetics with pre-existing mild gastroparesis [56]

Semaglutide In monotherapy trials with semaglutide injection for type 2 diabetes mellitus (T2DM), severe hypoglycemia (requiring the assistance of another person) was not reported in either the treatment group or the placebo group

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Quantitative in vitro assessment of N-alkyl sulphate-induced cytotoxicity in human keratinocytes (HaCaT)