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When a vitamin B12 injection is administered, the vitamin dissolves in the bloodstream and is quickly distributed throughout the body

Absolute deficiency occur up to 6% of those aged 60 years and older, whereas marginal deficiency occur in close to 20% of patients in later life ( Pernicious anemia is an autoimmune gastritis resulting from the destruction of gastric parietal cells and consequent impairment of intrinsic factors secretion to bind the ingested vitamin B12

doi: 10.1111/myc.12119 20 BarberA

This is the basis for twice-daily dosing

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