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Mori T, Akamizu T, Kosugi S, Sugawa H, Inoue D, Okuda J, et al
The patience required during dose escalation is actually one of the most valuable aspects of the protocol
Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)
While results can vary and more human studies are needed to validate many of the claims surrounding BPC-157, the early feedback and preclinical research suggest promising directionsespecially when it comes to natural recovery, resilience, and performance support
