The primary concern is cardiovascular stress: phentermine raises heart rate and blood pressure, while adding a GLP-1 receptor agonist can cause additional hemodynamic changes and increase the risk of arrhythmias or myocardial complications in susceptible individuals
in mammals, inflammasomes activate inflammatory caspases that promote interleukin-1 (IL-1) and IL-18 maturation and induce pyroptosis mainly through gasdermin D (GSDMD) cleavage
doi: 10.1002/art.38021 191 KohJHYoonSJKimMChoSLimJParkYet al
Stage 2 Clinical trials: results and side effects Published clinicaltrial research has reported weight reduction in participants receiving retatrutide compared with placebo
Rondanelli M, Perna S, Astrone P, Grugnetti A, Solerte SB, Guido D
doi: 10.1038/s41598-022-18398-z 3 MllerTDFinanBBloomSRD'AlessioDDruckerDJFlattPRet al