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Induction of COX-2 expression within Th17 cells is triggered by IL-23, facilitating the synthesis of Prostaglandin E2 (PGE2), a byproduct of arachidonic acid metabolism

Figure 1: analysis of c-Fos positive cells in the hypothalamus 2

These potential benefits include preserved eGFR, reversal of bone-mineral disorder, decreased risk of progression to dialysis, reduced urinary protein loss, decreased blood phosphate, and reduced all-cause mortality

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That price kept many patients from accessing the drug for years, even when clinically appropriate

Eli Lilly and Company, Sanofi, Novo-Nordisk A/S, AstraZeneca, Amgen, Inc.