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The PNMT gene is located on chromosome 17q12 and is composed of 4 exons that generate two alternatively spliced mRNAs, one of which is non-coding, the other encodes the functional protein of 282 amino acids
Because collagen is estimated to account for 30% or more of total body proteins5
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cytotoxicity data showed no toxicity to keratinocytes or fibroblasts across a six-log concentration range (0.0058 to 5800 micromolar) 3
Glycine requirements increase because it serves as a precursor for collagen, the most abundant protein in the body
One particularly serious concern is acromegalic cardiomyopathy, enlargement and weakening of the heart
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