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The first step is rate-limiting and subject to feedback inhibition by glutathione itself, holding intracellular concentrations in the low millimolar range, typically 1 to 8 mM (Griffith, Free Radical Biology and Medicine, 1999

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Fumonisn B1 (FB1) and B2 are of toxicological significance, while the others (B3, B4, A1 and A2) occur in very low concentrations and are less toxic [3]