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2002 Sep 1;101(1):7-10

PMID 10554220

Several studies have also shown that Nrf2 can directly regulate the availability of mitochondrial respiratory substrates, resulting in mitochondrial depolarization, reduced ATP levels, and impaired respiratory function

Liver is considered to be the primary site for the methylation of inorganic arsenic (iAs) and is shown to be critical specifically for the arsenic metabolism, and thus may be pharmacologically important as well

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