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Gao 2023 (human GLP1R-variant series) puts a number on it at the GLP-1 receptor: cAMP output saturates at roughly 10% (103%) receptor surface expression, so full effect sits far below full occupancy

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This is the second lot of loading doses Ive had in the last 2 years

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Your liver performs a small conversion step to make it bioactive, which is a normal physiological process for healthy adults