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It is the only GHRH analog with FDA-recognized studies specifically demonstrating its ability to reduce visceral adipose tissue (VAT) the dangerous fat that surrounds abdominal organs and is associated with cardiovascular disease, insulin resistance, and metabolic syndrome

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human long-term safety data is limited, so caution and monitoring are advised

Similarly, dysfunction of T2R9 due to a single nucleotide polymorphism is associated with higher blood glucose and insulin responses to an oral glucose tolerance test in Amish individuals with and without type 2 diabetes (38)

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In the cholesterol biosynthesis pathway, expression of genes such as lanosterol synthase ( Lss ), cytochrome P450, family 51 ( Cyp51 ), NAD(P) dependent steroid dehydrogenase-like ( Nsdhl ) and 7-dehydrocholesterol reductase ( Dhcr7 ) were decreased