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The significantly higher C max , C max /C trough , and AUC observed following morning Tac dose compared to night dose were in accordance with some previous reports ( To our knowledge, our study is the first showing the role of circadian rhythms on intracellular Tac PK

10.3389/fnins.2019.01443 Front

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In a study involving insomniac patients, Delta sleep inducing peptide administration reduced sleep latency by an average of 22 minutes (Anderer & Saletu, 1991)