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In obese individuals without diabetes mellitus, a once-weekly subcutaneous semaglutide (2.4 mg) dose had a significant body weight change compared with a once-daily subcutaneous liraglutide (3.0 mg) dose after 68 weeks
[5] [6] However, the absolute risk remained low , and the study's observational design could not definitively establish causation
Receptor sensitivity decreases with continuous stimulation
mean CD4 cell count was 639 cells/mm3
Therefore, this reductive effect is less likely to occur when blood sugar levels are stable, known as normoglycemia (7)
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