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Neither ratio has been validated in a human blend trial
[9] To be able to confirm possible cardiovascular benefits of DPP-4 inhibitors requires large, double-blind, randomized trials with formal adjudication of cardiovascular end points
This may include GLP-1 drugs or alternatives, such as metformin or bupropion
Like other peptide drugs, it is highly susceptible to degradation by digestive enzymes in the gastrointestinal tract
GLP-1 side effects can come along and spoil the fun
Therefore, metabolic improvements from acute and chronic administration of exendin-phe1 exceeded those of exendin-4
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