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In 2023, I wrote for STAT about GLP-1 shortages leading to treatment delays, interruptions, and difficult decisions about who deserved to get these precious medications
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However, these agents increase risk of intra-operative pulmonary aspiration according to a case report secondary to delayed emptying and presence of gastric residues despite fasting (108, 108) To prevent these events, the recent recommendations from the American Society of Anesthesiology guidelines suggest discontinuing GLP-1 receptor agonists 1 day prior in patients on daily dosing and 1 week prior in patients on weekly injection dosing (108)
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doi: 10.1038/s41591-023-02418-0 24
The 19 identified GLP-1 RA-related NAEs are not documented in approved labeling, expanding on prior evidence
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