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In naturally aged mouse models (1820 months old), daily oral administration of 5-amino-1mq capsules for 12 consecutive weeks significantly reduced NNMT activity and increased NAD+ levels in various tissues (liver, kidney, adipose tissue), along with markedly elevated expression of SIRT1 and SIRT3 proteins

Bock-Marquette et al., 2004 Documented accelerated regeneration of injured tendons, ligaments, and muscle fibers

Intravenous (IV) use is less common and only done in clinical settings

Design Single-center, retrospective, observational study

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These proteins form what is called an apoptotic blockade, meaning that cells cannot undergo apoptosis, even when they experience DNA damage that would normally trigger cell death