Those Experiencing Mood Issues: Vitamin B12 plays a role in brain health, so individuals dealing with mood swings, depression, or anxiety may find that B12 shots help improve their mental clarity and mood
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Frequency decreases to 5x per week during remodeling in weeks 58 and 2-3x per week during maintenance in weeks 912
However, in the pivotal Phase IIb trial, it failed to demonstrate statistically significant weight loss compared to placebo at the primary endpoint, leading the developer (Metabolic Pharmaceuticals Ltd.) to terminate the commercial program
MIC B12 injections cost $35$75 per shot
What we know today comes from two sources: controlled clinical trials (STEP, SELECT, SURMOUNT) and the collective experience of over 1.5 million Americans using these medications as of January 2026