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A joint clinical advisory published on PMC/NCBI from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society emphasizes that adequate protein intake is essential during this kind of rapid weight loss, specifically to help preserve muscle mass rather than losing both fat and muscle indiscriminately

The most important unknowns (cardiovascular safety, evidence on hard kidney outcomes, head-to-head tirals etc) all report between now and 2028

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Unlike many existing peptides that target a single receptor, Retatrutide is a triple agonist

The consistency of Retatrutide results in clinical trials was remarkable

According to FDA labeling for Wegovy (semaglutide), patients should be evaluated after 12 weeks at the maintenance dose (2.4 mg weekly), with discontinuation considered if less than 5% body weight reduction has been achieved